Desogestrel side effects: A complete guide

DoktorABC editorial team

Accurate, up-to-date health information written by our editorial team and reviewed by UK-registered prescribers.

Desogestrel side effects: Frequency overview

Frequency classifications below are drawn from the desogestrel Summary of Product Characteristics at medicines.org.uk.

What are the very common side effects of desogestrel?

The most frequently reported side effect is a change in bleeding pattern. This can mean irregular or unpredictable spotting, lighter or heavier periods, or periods stopping altogether. These changes occur because desogestrel thins the uterine lining over time and are most common in the first three months. Amenorrhoea is experienced by approximately one in five women on desogestrel and is not harmful.

What are the common side effects of desogestrel?

Acne: Desogestrel can cause or worsen acne in some women, particularly in the early months of use.

Headache and nausea: Both are common when starting desogestrel and typically improve after the first few months. Taking the pill at the same time each day, ideally with food, can help reduce nausea.

Breast tenderness: A common hormonal side effect that usually reduces as the body adjusts.

Mood changes and depression: Mood changes, including low mood and depression, are listed as common side effects. The MHRA has noted mood changes as a class-wide consideration for progestogen-containing contraceptives.

Decreased libido: A reduction in sex drive is a recognised hormonal side effect that typically improves if the pill is discontinued.

Weight changes: Weight gain is listed as common, though the direct causal evidence is limited. Individual responses vary.

What are the uncommon side effects of desogestrel?

Uncommon side effects include contact lens intolerance (related to fluid retention affecting eye shape), vaginal dryness, and ovarian cysts. Ovarian cysts associated with desogestrel are usually benign and often resolve without treatment.

How long do desogestrel side effects last?

The first three months are typically the most pronounced as the body adjusts to a new hormonal environment. Effects such as irregular bleeding, headache, nausea, and breast tenderness often improve significantly after this period. If significant side effects persist beyond three months, speak to your prescriber about whether desogestrel is the right choice for you.

What are the side effects of coming off desogestrel?

Coming off desogestrel is not associated with a formal withdrawal syndrome, but some women notice a period of readjustment. For a full overview of what to expect when stopping hormonal contraception, see our coming off the pill guide.

Return of periods: Periods typically return within one to three months of stopping, though this varies. Some women's cycles take longer to re-establish.

Mood readjustment: Some women experience a brief period of mood fluctuation as the body readjusts to its natural hormonal cycle, usually settling within one to two cycles.

Fertility: Returns quickly after stopping. You can become pregnant as soon as ovulation resumes, which may happen before your first period returns.

What happens if you accidentally take a double dose of desogestrel?

Taking two tablets in one day is unlikely to cause serious harm. No serious adverse effects have been reported following accidental overdose. You may experience temporary nausea or spotting. Continue your pack as normal and speak to a pharmacist or call NHS 111 if you are concerned.

When should you stop taking desogestrel and see a doctor?

Stop taking desogestrel and seek prompt medical attention if you experience severe abdominal pain, signs of a severe allergic reaction (swelling of the face, lips or throat, or difficulty breathing), persistent depression or thoughts of self-harm, jaundice, or significant vision changes if you wear contact lenses.

Final thoughts

Desogestrel is well tolerated by many women, but its side effect profile is worth understanding before starting. Irregular bleeding is the most common reason women discontinue it, and mood changes deserve honest acknowledgement. Most side effects improve after the first three months. If they do not, a prescriber can help you find an alternative. For a broader overview of side effects across all mini pill types, see our mini pill side effects guide. 

DoktorABC connects UK patients with licensed prescribers who can assess suitability for desogestrel and other contraceptive options, and issue private prescriptions where clinically appropriate.

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The DoktorABC medical advisory board

Dr. Roland Ruiken

Medical advisor, Norway

Dr. Viktor Simunovic

Medical advisor, Croatia

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