The both active components in Malarone are Atovaquone and Proguanil.
GlxoSmithKline is the Pharma Company behind Malarone. They developed the drug to avoid Malaria infections with the help of the two components.
Malarone is suitable for travellers who want to protect themselves last minute, cause maybe you didn’t have in mind that you’re travelling into an affected area. You need to start the medication at least two days before your trip starts. Malarone is known to cause less side effects than other medication which protects against the malaria parasite but therefore it is more expensive.
Malarone is a kind of medicine, which prevents from an infection with the Malaria parasite. The active components for the treatment are Atovaquone and Proguanil. Atovaquone is responsible for blocking a certain stage in the reproduction circle of the parasite. This makes sure the Malaria parasite can’t procreate any more. Proguanil inhibits an enzyme which is needed by the parasite to multiply. So both active components operate together and fight the procreation of the parasite. In this way Malarone provides you from infection and gives you a relatively sure protection against Malaria.
Fitting people for taking Malarone
People travelling to malaria-affected regions are usually interested in taking Malarone. But you need to be careful because it is not recommended for everyone. Both breastffeding and pregnant woman shoudn’t take Malarone. The same is suggested for children. To be sure you’re a fitting person for the treatment with Malarone ask your doctor. He needs to check all possible criteria for exclusion. Especially your current health and your former medical history play a big role for the decision.
Possible Advantages of Malarone
In contrast to Doxycycline you need to take Malarone for at least 7 days after the trip into an affected area. Other medications need to be taken for one month after travelling. Some people also prefer the fact that you take Malarone daily and not weekly because it is easier to remember.
Dose Instructions for Malarone
Each day while treating your disease, you should take one tablet of Malarone. Start the medication at least two days before your trip into a Malaria affected region starts. To achieve the best protection take one pill for the duration of your trip and for at least seven days after your stay. Don’t worry if you miss one dose a day. Take the forgotten tablet as soon as you remember unless it is too close to your next dose. If this is the case skip one dose and continue like you are used to. But please remember that full protection can only be given as long as you take the pills as continuously as possible. Be careful with sickness. If you got diarrhoea or you have to vomit one hour after taking Malarone take another dose. If you got the impression that you took an overdose and you do not feel well, please seek for medical help. There is also a paediatric kind of Malarone available. This one got a lower dose and is made for children with 11 to 40 kg. The rules for taking any dose are the same as for adults. Children should take there pill with food.
Possible side effects of Malarone
Like all medicines, this medicine can cause side effects, although not everybody gets them. Look out for the following severe reactions. They have occurred in a small number of people, but their exact frequency is unknown.
Severe allergic reactions - signs include:
- rash and itching
- sudden wheezing, tightness of the chest or throat, or difficulty breathing
- swollen eyelids, face, lips, tongue or other part of the body.
Contact a doctor immediately if you get any of these symptoms. Stop taking Malarone.
Severe skin reactions
- skin rash, which may blister and looks like small targets (central dark spots, surrounded by paler area with a dark ring around the edge) (erythema multiforme)
- severe widespread rash with blisters and peeling skin, particularly occurring around the mouth, nose, eyes and genitals (Stevens-Johnson syndrome).
If you notice any of these symptoms contact a doctor urgently.
Most of the other side effects reported have been mild and have not lasted very long.
Very common side effects
These may affect more than 1 in 10 people:
- feeling sick and being sick (nausea and vomiting)
- stomach pain
Common side effects
These may affect up to 1 in 10 people:
- sleeping problems (insomnia)
- strange dreams
- loss of appetite
- rash which may be itchy
Common side effects, which may show up in your blood tests are:
- reduced numbers of red blood cells (anaemia) which can cause tiredness, headaches and shortness of breath
- reduced numbers of white blood cells (neutropenia) which may make you more likely to catch infections
- low levels of sodium in the blood (hyponatraemia)
- an increase in liver enzymes.
Uncommon side effects
These may affect up to 1 in 100 people:
- an unusual awareness of abnormal beating of the heart (palpitations)
- swelling and redness of the mouth
- hair loss.
Uncommon side effects that may show up in your blood tests:
- an increase in amylase (an enzyme produced in the pancreas).
Rare side effects
These may affect up to 1 in 1,000 people:
- seeing or hearing things that are not there (hallucinations)
Other side effects
- Other side effects have occurred in a small number of people but their exact frequency is unknown.
- Inflammation of the liver(hepatitis)
- blockage of the bile ducts (cholestatis)
- increase in heart rate (tachycardia)
- inflammation of the blood vessels (vasculitis) which may be visible as red or purple raised spots on the skin but can affect other parts of the body
- fits (seizures)
- panic attacks, crying
- severe mental health problem in which the person loses contact with reality and is unable to think and judge clearly
- mouth ulcers
- peeling skin
- increased sensitivity of the skin to sunlight.
Other side effects that may show up in your blood tests:
- A decrease in all types of blood cells (pancytopenia).
A more detailed list of side effects can be found in the patient information.
The Patient Information Leaflet (PIL) is the leaflet included in the pack with a medicine. It is written for patients and gives information about taking or using a medicine. It is possible that the leaflet in your medicine pack may differ from the PDF-version from this website because it may have been updated since your medicine was packaged or the medicine is from another brand.