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Condyline

Condyline

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About Condyline

Condyline 0.5% is a potent antiviral topical cream used in sexually transmitted diseases such as genital warts and molluscum contagiosum. 

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In order to buy this prescription medicine you need to fill in the online questionnaire by clicking on “Buy Online Now”. Our doctors will evaluate your data and prescribe the according medication for you. The prescription will be sent to a pharmacy and your medication will be delivered to the address of your choice on the next day.

Detailed product information

What is Condyline 0.5%?

Condyline 0.5% is a medical topical cream that contains podophyllotoxin in vials of 3.5 ml used in the treatment of sexually transmitted diseases such as genital warts (condyloma acuminata) and molluscum contagiosum. Podophyllotoxin is a plant extract that helps the warts’ growth stop and shrivel. Every pack contains 3.5ml of Condyline 0.5% plus plastic stick aplicators. 

What other ingredients or excipients does Condyline 0.5% contain?

  • Ethanol 96%
  • Lactic acid
  • Sodium lactate 60% solution

What are genital warts?

Genital warts are also referred to as condyloma acuminata or venereal warts. Genital warts are one of the most common sexually transmitted dermatological lesions that appear in the genital area due to the human papillomavirus (HPV). They may appear as small,  flesh-colored bumps, small and flat lesions or a cluster of several warts that makes a cauliflower like form in both women and men. In women they will grow on the vulva, in cervix, vaginal walls and anal area. In men, lesions may appear in the gland or tip of penis, the shaft, scrotum or the anus. They may also be found in new born babies in their larynx and throat and mouth in men and women who practiced oral sex with an infected person. Genital warts have no cure and some strands have a high association with cervical and penile cancers, therefore treating this disease is very important.

What causes genital warts?

Genital warts are caused by a type of virus called HPV: Human papillomavirus. There are over 100 types of HPV and of these, 35 types are associated with genital warts. HPV types are divided into two categories.  Low risk benign HPV lesions and high risk neoplastic HPV lesions. 

Low risk benign HPV lesions: The most common types are HPV 6 and 11. They make up approximately 90% of genital warts and recurrent respiratory papillomatosis (RRP) cases.

RRP is an uncommon disease in which warts will appear throughout the respiratory tract. 

High risk neoplastic HPV lesions: HPV 16 and 18 are the most common types that lead to cancer lesions. Recent studies have shown that 70% of vaginal, cervical and penile cancers are caused by these 2 types of HPV. 

How common is it?

According to the World Health Organization (WHO) and Centers for Disease Control and Prevention (CDC),  2/3 of sexually active people will get infected. Being a very contagious disease it is mostly found in people in reproductive ages mostly around 17 and 33 years of age. 

How is it transmitted and what are the risk factors? 

Being a sexually transmitted disease, it is transmitted through vaginal, anal and oral intercourse. Because it affects different parts of the genital area, condoms do not protect entirely against this disease. Both male and women are equally affected, and it is most common in people in reproductive ages between 17 and 33 years of age. Having unprotected sex with multiple partners or partners whose sexual history is unknown to you are risk factors for becoming infected with this disease. Other risk factors are initiating sexual intercourse at an early age, multiple partners, smoking, use of oral contraceptives, weakened immune system, and children from infected mothers who were infected during childbirth. 

What are the signs and symptoms of genital warts? 

Genital warts are usually painless, but they are uncomfortable because of the itching sensation they produce, the size or the location they are in. Some of the symptoms you might feel are:

  • Painless bumps or lesions in vagina, vulva, anus, penis, scrotum, larynx
  • itching
  • vaginal, anal or discharge in penis
  • urinary tract infections
  • bleeding during intercourse
  • vaginal or penile discharge
  • irregular intermenstrual cycles
  • fatigue
  • weight loss
  • loss of appetite
  • Other sexually transmitted diseases

How long does it take for genital warts to appear?

Genital warts may appear days after sexual contact, in other cases it can take some months for them to be present. Other people may get infected with the virus but never get genital warts. 

What are the complications?

The most important complication is the association of genital warts with cancer. It is known to cause cervical, vaginal and penile cancer. Cervical cancer is the second most common cancer in women making u over 445,000 cases in the world. Recent studies have shown that up to 270,000 deaths in 2012 can be accounted to cervical cancer. 

Other complications are:

  • Neoplastic lesions
  • Recurrent genital warts: After being treated, there is a risk of 19% recurrence rate after 3 months and up to 23% after 6 months. There are lesions that hare hidden in genital area that makes the virus reproduce itself again infecting other parts of the body and partners through contact.
  • Aesthetic problems such as disfiguration of the area where the warts are located.
  • Transmission to newborn babies through childbirth

How can genital warts be prevented?

There are over 100 types of this virus, but there are currently 2 vaccines in the market that protect you against the most common types of HPV virus up to more than 50%. 

Gardasil 9: protects you against 9 HPV strains. It is recommended n women from 9 to 26 years of age for the prevention of genital warts, precancerous lesions and cervical cancer. In males from 9 to 26 years is used for the prevention of genital warts, precancerous lesions and anal cancer. Cervarix: Is used to protect you against the high risk neoplastic strains 16 and 18 that are associated with cervical cancer. It is recommended in people from 9 to 26 years of age as prevention for this lesions. 

Other ways to protect yourself from being infected are:

  • Using barrier preservatives such as condoms when having sexual intercourse. Even though it doesn’t protect you 100% from acquiring the disease, it will protect the parts that cover the condom. The other types of birth control methods such as pills, diaphragms and others will not protect you against genital warts.
  • Know the history of your sexual partners.
  • Be in monogamous relationships
  • Limit the number of your sex partners
  • Do not smoke, abuse alcohol or use drugs
  • Avoid the use of douches: Douches are known to eliminate the normal bacteria in your vagina which protects you against sexually transmitted diseases, therefore douching is not recommended.

It is important to know that following all of these steps will help you be protected against HPV and its complications. All of these tips work together in conjunction to protect you better than just following one.

What should you do if you are pregnant and have genital warts?

If you’re pregnant and suffer from genital warts, it is important for you to visit a GP or a OB/GYN to treat your disease. There are many treatments that can’t be used because there aren’t enough tests available to see if they can or will affect you or your baby. Over the counter medicines should be taken with precaution and a doctor will give you the best treatment for you. If you leave your genital warts untreated, it can bring serious complications to your child. It may get infected through childbirth and acquire recurrent respiratory papillomatosis. Warts will appear in its air way and can grow to sizes that will block the airway and not allow it to breath correctly that can lead to death. 

What is the long term outcome of genital warts?

Genital warts that are visible may be removed and never reappear. There are chances that if your immune system is not strong enough to fight the virus it may stay dormant and you will suffer genital warts in many occasions throughout your life time. If you still have the virus in your body you may still infect yourself in other parts of your body and others. Therefore it is advised to take the medication as prescribed and visit a doctor to gibe you the best medicine that will suit you. 

Are there any special precautions to be taken while using this medication?

  • Hypersensitivity: If you are allergic to any of the components of Condyline 5%, it is advised you use another type of medication.
  • Medical interactions: There are no known medical interactions while using this medication, but be sure to tell your doctor if you use any type of medication before starting to use Condyline 5%.
  • Pregnancy and breastfeeding: There are no studies made over the effects of Condyline 5% in women who are pregnant or breastfeeding, therefore it is not recommended to be used.
  • Age: It is not recommended to be used in children under 12 years of age.
  • Skin: It should not be used in healthy skin, open wounds, bleeding skin or inflamed skin.
  • Not to be used if you have too many warts unless your GP tells you to.

Sources:

  • https://www.medicines.org.uk/emc/product/492/smpc#OVERDOSE
  • https://www.drugs.com/uk/condyline-0-5-w-v-cutaneous-solution-leaflet.html
  • https://imedi.co.uk/condyline-0-5-w-v-cutaneous-solution/summary
  • https://www.ncbi.nlm.nih.gov/pubmed/7548288
  • http://www.medsafe.govt.nz/Consumers/cmi/c/condyline.pdf
  • https://www.hpra.ie/img/uploaded/swedocuments/LicenseSPC_PA0838-004-001_10062015142036.pdf
  • https://reference.medscape.com/drug/condylox-podofilox-343553#5

How should Condyline 5% be used? 

Recommended dosage is to apply the cream in the warts twice a day (every 12 hours) for three days.  After completing the three day treatment, you can resume the treatment after four to seven days. 

Be sure to follow this steps to have better results.

  • Wash the affected area and hands with soap and water.
  • Let the affected area dry well.
  • Dip the plastic stick applicator into Condyline 5% solution. Do not put the solution on healthy skin or more than needed. If so, wash the area with plenty soap and water.
  • Put the liquid of the applicator on to the wart or warts. It is not recommended to use this medication more than 50 times or dips.
  • Let the medication dry.
  • Wash your hands with soap and water and avoid contact with eyes, nose or mouth. 

What should you do if the treatment wasn’t effective?

If the warts did not disappear by the first week, you can repeat the treatment for 5 weeks. Always leaving a week in between the treatments. It is not advisable to use this treatment for longer periods of time unless your GP tells you otherwise.

What should you do if you forget to use Condyline 5%?

If you forget an application of Condyline, use it as soon as you remember. If it is time close to the second application, then skip the treatment you missed and continue your treatment. Do not use double the dose to make up for the one you forgot.

Are there risks of overdose while using Condyline 5%?

Condyline 5% is a topical medicine, meaning it should only be used in the skin and in small areas at once. If you use more medicine than recommended topical overdose may occur. The symptoms that may present are abdominal pain, diarrhea, nausea and vomiting. Serious side effects such as blood alterations including thrombocyptopenia, and leukopenia may occur. Cases of renal and hepatic failure have been reported in overdose cases. Neurological alterations sch as dizziness, seizures a, coma, ataxia and hypotonia may be present. Other serious symptoms are tachychardia, orthostatic hypotension, apnea, and urinary retention.

If you or anyone you know have ingested this medication, be sure to seek medical help immediately.

There are mild side effects after using the vaccine such as mild pain in the location of the injection, redness and allergic reaction to the injection, myalgia, fatigue and headaches have been reported.

Side effects of Condyline are:

  • Inflammation of the foreskin and head of the penis
  • Local irritation of the vagina
  • Mild irritation of your warts shortly after applying the solution. This may include itching, burning, pain, redness or ulcers on the skin
  • Although it is unlikely, some people may experience an allergic reaction to the active ingredient podophyllotoxin - this may be severe and painful redness or irritation, or any other unexpected pain.

Leaflet info
The Patient Information Leaflet (PIL) is the leaflet included in the pack with a medicine. It is written for patients and gives information about taking or using a medicine. It is possible that the leaflet in your medicine pack may differ from the PDF-version from this website because it may have been updated since your medicine was packaged or the medicine is from another brand.

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